The book begins with a historical overview, which begins with the destruction of Jerusalem in AD 70, covers the Reformation and Advent movement in detail, and culminates with a lengthy description of the end times.
Much of the first half of the book is devoted to the historical conflict between Roman Catholicism and Protestantism. White writes that the Papacy propagated a corrupt form of Christianity from the time of Constantine I onwards and during the Middle Ages was opposed only by the Waldensians and other small groups, who preserved an authentic form of Christianity. Beginning with John Wycliffe and Jan Huss and continuing with Martin Luther, Huldrych Zwingli, and others, the Reformation led to a partial recovery of biblical truth.
The second half of the book is prophetic, looking to a resurgence in papal supremacy. The civil government of the United States will form a union with the Roman Catholic church as well as with apostate Protestantism.